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Galantamine Hydrobromide 1953-04-4
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM)
and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target:
AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells.
Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model
of Alzheimer's disease.
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